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Common molecules sample 50729 - Reciprocal Net Log in
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Empirical formula: C26H30NO
a: 15.998 Å
b: 21.964 Å
c: 8.624 Å
α (alpha): 90.00 °
β (beta): 96.28 °
γ (gamma): 90.00 °
Volume: 3012.12 Å3
Space group: P21/c
Calculated density: 0.821 g/cm3
Z: 4
Temperature: 22.0 °C
Formula weight: 372.530 g/mole
R(F): 0.0440
Common name: Tamoxifen
CSD refcode: FUPDOJ
Keyword: anti-estrogen
Keyword: SERM
Layman's explanation: Tamoxifen, a synthetic non-steroidal antiestrogen, was first synthesized at ICI Pharmaceuticals in England as a contraceptive pill, but is used today to treat estrogen-receptor-positive breast cancers, which require estrogen to grow and reproduce. Tamoxifen is a selective estrogen receptor modulator (SERM) that competes with estrogen to bind at estrogen receptor sites on cancer cells. In doing so, the growth and spread of cancer can be greatly slowed or diminished. Unfortunately, the mechanism of antiestrogen action is not fully understood.
IUPAC name: (Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethylamine
Citation of a publication: Reference: J.Pharmaceutical Sci.,76,(1987) p259 Authors:I.Goldberg, Y.Becker
Lab name: Common molecules
Sample provider: Obtained courtesy of the Cambridge Structural Database
Status: Complete, visible to public
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Repository Files:
50729.gif 50729.GIF 50729.ort
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