Phosphoenolpyruvate (PEP) is an important biological molecule that was discovered by Merton Franklin Utter in 1917. PEP has various functions as a regulator. In certain plants this molecule plays a role in the regulation carbon dioxide concentration and pH. PEP is also important in the regulation of carbohydrate and lipid metabolism in various organisms. In flowering plants PEP plays an important role in gluconeogenesis, especially in the storage of fat in fruit. A low concentration of PEP in animals can cause hypoglycemia. Recently PEP has been used for its therapeutic benefits in the treatment of malignant tumors, haemal illnesses, various infections, immunological diseases such as HIV infection, and in homeopathy.
Copyright notice:
J. Biol. Chem., Vol. 278, Issue 25, 22703-22708, June 20, 2003
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Common molecules
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Obtained courtesy of the Cambridge Structural Database
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