Common molecules sample 50714

You will need to download and install a Java plug-in in order to view this applet. Download Sun's Java plug-in from here.

Switch to another visualization applet:

Empirical formula:	C₁₀H₁₃N₅O₄
a:	5.711 Å
b:	11.996 Å
c:	17.664 Å
α (alpha):	90.00 °
β (beta):	94.30 °
γ (gamma):	90.00 °
Volume:	1206.74 Å³
Space group:	P21
Calculated density:	1.471 g/cm³
Z:	4
Temperature:	22.0 °C
Formula weight:	267.245 g/mole
R(F):	0.0340
Common name:	AZT
CSD refcode:	FIXGAU02
Keyword:	anti-HIV
Short description:	AZT is one of the most commonly used anti-HIV drugs.
Keyword:	anti-viral
Miscellaneous comments:	Hydrogen atoms were added using HFIX from XSeed.
Layman's explanation:	AZT, or azidothymidine, was first developed by Jerome Horowitz in 1964. It was initially not designed as a drug to combat HIV, but rather, for the National Cancer Institute as cancer chemotherapy. AZT was discovered from a herring and salmon sperm extract. Its activity was not initially described until 1985, and it soon became the first anti-HIV drug approved for use in the United States. Azidothymidine is a nucleoside analogue which acts as a reverse transcriptase inhibitor. It blocks the replication of the genetic material necessary for a cell to divide. AZT is used as an anti-HIV drug due to its anti-viral qualities and ability to prevent cellular division.
IUPAC name:	3'-Azido-3'-deoxythymidine
Citation of a publication:	A.Camerman, D.Mastropaolo, N.Camerman; Proc.Nat.Acad.Sci.USA, 84, (1987), 8239
Lab name:	Common molecules
Sample provider:	Obtained courtesy of the Cambridge Structural Database
Status:	Complete, visible to public

Repository Files:
50714.cif	50714.crt	50714.GIF	50714.ort	50714.PDB
50714.sdt	50714f.crt	50714f.pdb	50714f.sdt