Common molecules sample 50729

You will need to download and install a Java plug-in in order to view this applet. Download Sun's Java plug-in from here.

Switch to another visualization applet:

Empirical formula:	C₂₆H₃₀NO
a:	15.998 Å
b:	21.964 Å
c:	8.624 Å
α (alpha):	90.00 °
β (beta):	96.28 °
γ (gamma):	90.00 °
Volume:	3012.12 Å³
Space group:	P21/c
Calculated density:	0.821 g/cm³
Z:	4
Temperature:	22.0 °C
Formula weight:	372.530 g/mole
R(F):	0.0440
Common name:	Tamoxifen
Keyword:	anti-estrogen
Keyword:	SERM
Short description:	Tamoxifen has been used in treatment of breast cancer interfering with the activity of estrogen.
CSD refcode:	TTAMOX01
IUPAC name:	(Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethylamine
Citation of a publication:	I.Goldberg, Y.Becker; J.Pharmaceutical Sci., 76, (1987), 259
Layman's explanation:	Tamoxifen is a synthetic non-steroidal antiestrogen that was first synthesized at ICI Pharmaceuticals in England as a contraceptive pill. Today this drug is used to treat estrogen-receptor-positive breast cancers, which require estrogen to grow and reproduce. Tamoxifen is a selective estrogen receptor modulator (SERM) that competes with estrogen to bind at estrogen receptor sites on cancer cells. In doing so, the growth and spread of cancer can be greatly slowed or diminished. Unfortunately, the mechanism of antiestrogen action is not fully understood.
Lab name:	Common molecules
Sample provider:	Obtained courtesy of the Cambridge Structural Database
Status:	Complete, visible to public

Repository Files:
50729.cif	50729.crt	50729.gif	50729.GIF	50729.ort
50729.pdb	50729.sdt	50729.txt