Amphidinolide H is in a class of natural products that includes 34
macrolides (amphidinolides A - H, J - W, B3, and caribenolide I). It is a
cytotoxic molecule that was first isolated from various strains of the
microscopic marine dinoflagellate Amphidinium. It exhibits significant in
vitro antineoplastic (anticancer) activity against murine lymphoma L1210, human
epidermoid carcinoma KB, and human colon tumor cells HCT116. Sadly though, it
is found in incredibly minute amounts in microscopic marine flatworms that live
off the coasts of Japan and the U.S. Virgin Islands. Many researchers are
exploring alternative avenues of collecting this molecule, especially
through synthesis. However, there have been very few researchers that have been successful, and the methods by which it has been synthesized are
inefficient.
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