Common molecules sample 50616

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Empirical formula:	C₄H₃F₁N₂O₂
a:	9.220 Å
b:	12.660 Å
c:	12.670 Å
α (alpha):	89.70 °
β (beta):	43.90 °
γ (gamma):	98.60 °
Volume:	1000.08 Å³
Space group:	P-1
Calculated density:	1.728 g/cm³
Z:	8
Formula weight:	130.079 g/mole
R(F):	9.2000
Trade name:	Adrucil
Common name:	5-Fluorouracil
CSD refcode:	FURACL
Short description:	5-Fluorouracil is an antimetabolite used to treat cancer.
Keyword:	chemotherapy
Keyword:	cancer
Layman's explanation:	5-Fluorouracil has been in use for several decades and is one of the oldest currently used chemotherapy drugs. Two popular forms in use today are Adrucil , an intravenous form, and Efudex in a skin cream form. 5-Fluorouracil is an antieoplastic antimetabolite, which works by inhibiting the growth of cancer cells by interfering with the production of DNA and RNA by blocking the synthesis of nucleic acids. Unfortunately, it interferes with healthy cells and is an immunosuppressant. The drug is administered by injection, infusion, orally or as a cream to treat colon, rectum, breast, stomach, skin and pancreas cancer. Common side effects include: reduced red blood cell count, hair loss, loss of appetite, weight loss, headache, and dry and darkening of the skin.
Citation of a publication:	Reference: Acta Crystallogr.,Sect.B., 29 (1973) p2549 Authors: L. Fallon III
Lab name:	Common molecules
Sample provider:	Obtained courtesy of the Cambridge Structural Database
Status:	Complete, visible to public

Repository Files:
50616.cif	50616.crt	50616.GIF	50616.pdb	50616.sdt
50616f.crt	50616f.sdt	50616f.tab